بررسی ارتباط کیفیت خواب با اینترلوکین-1 بتا و پروتئین واکنشی–C در مردان فعال و غیرفعال

Background and Objective: Studies indicated that physical activity influences sleep quality and inflammatory markers, but not have been studied much the relationship between sleep quality and inflammatory markers caused by physical activity. The aim of the present study was to investigate the relationship between sleep quality with interleukin-1β and C - reactive protein in active and non-active men. Material and Methods: The present study is cross-sectional. Twenty-two healthy males aged 32-38 years participated voluntarily in this study, and were divided into two non-active (n=11) and active (n=11) groups. The non-active group were without sports history and the active group had more than two years of moderate-intensity aerobic exercise history (moderate aerobic training 45 minutes/day, 3days/week). Fasting blood samples were taken from all subjects. Serum C-reactive protein and interleukin -1 beta was measured by ELISA method and Pittsburg Sleep Quality Index Questionnaire (PSQI) was used to evaluate sleep quality. The research data were analyzed using the independent t test, Pearson’s correlation coefficient and Multiple Linear Regression. Results: IL-1β (p=0.015) and CRP (p=0.043) concentrations under the effect of physical activity in the active group compared to the non-active group showed a significant decrease. The Sleep Quality Index score was significantly lower in the active group compared to non-active group (p=0.021). A Significant relationship was observed between sleep quality score, IL-1β (r=0. 571, p=0. 033) and CRP (r=0. 613, p=0. 012) concentrations in active men. Conclusion: The present study demonstrates that there is a significant relationship between sleep quality with IL-1β and CRP levels in active men so that it may improve sleep quality by reduction in inflammatory markers. Key words: Inflammatory factors, Sleep quality, Physical activity Funding: This research was funded by personal costs. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Urmia University approved the study.   How to cite this article: Tartibian B, Kamrani A, Yaghoobnezhad F, Mohammad Amini S. Investigation of the Relationship between Sleep Quality with Interlukin-1β and C - Reaction protein in Active and Non-Active Men. J RafsanjanUniv Med Sci 2014 13(2): 141-50 [Farsi]